If you're a fan of great comics, please be like Terry/snoid and don't let the fact that we're gigantic assholes keep you from trying the TCJ Winter Special. There are a lot of really good comics in there, like Tony's and Joe Sacco's. It's a great sampler for people interested in checking out alternative comics. The written parts are notably asshole-free, too, for the most part.
Sock Monkey is a great read, too, and that's done by Dark Horse. I'm pretty sure Diana Schutz is the editor, and she's totally well-liked, so you're safe there. I still think about that page in Volume 3 with the sock monkey running with scissors, and that comic came out more than a year ago. Tony Millionaire's a first-tier cartoonist. Collect them all!
Chris, here's a suggestion for an indy comic you may not have heard about: Supermonster #14, titled "Gloriana Comics" by Kevin Huizenga. It's a very thick self-published comic, $3. I re-read it last night. On the one hand, Huizenga's work is charmingly drawn slice of life. On the other, it's hugely formally ambitious and deeply thoughtful. One story juggles an enormously fun scientific explanation of why the moon turns red and looks big, the narrator looking at that phenomenon, and the narrator talking to his wife about explaining the phenomenon to some other onlookers -- all in the same scene! It's really charming, great stuff, and I think you'll hear a lot more from this cartoonist in the next few years. (PO Box 12299, St. Louis, MO 63157)
Kevin's comic can be seen in part and even ordered at the USS Catastrophe comics site, but they really demand the tactile experience for a full appreciation.