I'm surprised superhero fans would have any trouble with the premise, actually.
I don't have a problem with the premise. I have a problem with the soap operatic format's lack of interest in and adherence to the premise. I wanted to see a story about people surviving on an island, sort of a more serious version of Gilligan's Island. Instead I got a bunch of pointless flashbacks and "mysterious" mumbo-jumbo that was never answered. It really was the equivalent of the "Who shot JR?" episode of Dallas, but every episode. When a character stands there for five minutes and says, "I don't understand...," while another character or characters is smiling graciously, the writers don't have a fucking clue what they're doing.
I've been asking around to see how people reacted to the finale. Turns out, I don't know anybody who watched Lost. Some said their girlfriends, wives or daughters did, though. Very strange.